This Error event indicates that the specified performance counters for the Microsoft Exchange Mail Submission service could not load.

This error may be caused by one or more of the following conditions:

• One or more performance counters for the Microsoft Exchange Mail Submission service are enabled. However, the Microsoft Exchange Mail Submission service is stopped or not responding.
  
  
• The registry key that controls the specified performance counters is missing, is corrupted, or has insufficient permissions assigned to it.
  
  The Microsoft Exchange Mail Submission service performance counters are located in the following registry subkey: HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\MSExchangeMailSubmission\Performance
  
  By default, the following permissions are assigned to this registry subkey:
  
  
  • Administrator: Full Control
    
    
  • Administrators: Full Control
    
    
  • Authenticated Users: Read
    
    
  • Creator Owner: Full Control
    
    
  • Domain Admins: Full Control
    
    
  • Enterprise Admins: Full Control
    
    
  • Exchange Organization Administrators: Full Control
    
    
  • System: Full Control
    
    
  • The server's Computer Account: Read
    
    
  • Exchange Servers: Read
    
    
  • Exchange View-Only Administrators: Read
    
    
  • Server Operators: Special permissions: All permissions except: Full Control, Create Link, Write DAC or Write Owner.
    
    

To resolve this error, use one or more of the following methods:

• Restart the Microsoft Exchange Mail Submission service.
  
  
• Unload and reload the Microsoft Exchange Mail Submission service performance counters. To do this, follow these steps:
  
  
  1. At a command prompt on the Hub Transport server, run the following command:
     
     Unlodctr MSExchangeMailSubmission
     
     The successful completion of this step should generate the following Application event log entry:
     
     Source: LoadPerf
     
     Event ID: 1001
     
     Description: Performance counters for the MSExchangeMailSubmission (Microsoft Exchange Mail Submission) service were removed successfully. The Record Data contains the new values that are assigned to the system Last Counter and Last Help registry entries.
     
     
  2. Run the following command:
     
     Lodctr "C:\Program Files\Microsoft\Exchange Server\Setup\Perf\MailSubmissionSvcPerfCounters.ini"
     
     The successful completion of this step should generate the following Application event log entry:
     
     Source: LoadPerf
     
     Event ID: 1000
     
     Description: Performance counters for the MSExchangeMailSubmission (Microsoft Exchange Mail Submission) service were loaded successfully. The Record Data contains the new index values assigned to this service.
     
     
  3. Restart the server to put the changes into effect.
     
     
• Verify that the registry key for the Microsoft Exchange Mail Submission service performance counters exists and has the correct permissions assigned to it.
  
  

If you are not already doing so, consider running the Exchange tools created to help you analyze and troubleshoot your Exchange environment. These tools can help make sure that your configuration aligns with Microsoft best practices. They can also help you identify and resolve performance issues, improve mail flow, and better manage disaster recovery scenarios. To run these tools, go to the Toolbox node of the Exchange Management Console. To learn more about these tools, see Managing Tools in the Toolbox.