This Error event indicates that the Microsoft Exchange Mail Submission service is not running. The Microsoft Exchange Mail Submission service submits messages from the Mailbox server to Microsoft Exchange Server 2010 Hub Transport servers. This service is dependent upon the Microsoft Exchange Active Directory Topology service. 

This error typically occurs when the .NET components try to verify a CRL distribution point. If the server that is hosting the CRL distribution points does not have connectivity to the Internet, or if the verification process takes too long, a time-out error occurs and prevents the Exchange Mail Submission service from starting.

To resolve this error, use one or more of the following methods:

• Try to manually start the Microsoft Exchange Mail Submission service in the Services console.
  
  You may have to modify the configuration file. The configuration file for Mail Submission service should exist in the Microsoft\Exchange Server\Bin folder. The file is named MSExchangeMailSubmission.exe.config. You must modify the existing file by adding the following line to the runtime options section:<generatePublisherEvidence enabled="false"/>After you add this entry, the runtime options section resembles the following example:<configuration> <runtime><generatePublisherEvidence enabled="false"/><Other entries></runtime> </configuration>
  
  
• Review the Application log and System log on your Exchange 2010 servers for related events. For example, events that occur immediately before and after this event may provide more information about the root cause of this error.
  
  
• Review the Operations Console in Operations Manager for detailed information about the cause of this alert. For more information, see the "Introduction" section in this topic.
  
  
• Resolve your issue by using self-support options, assisted support options, and other resources. You can access these resources from the Exchange Server Solutions Center. From this page, click Self-Support Options in the navigation pane to use self-help options. Self-help options include searching the Microsoft Knowledge Base, posting a question at the Exchange Server forums, and others. Alternatively, in the navigation pane, you can click Assisted Support Options to contact a Microsoft support professional. Because your organization may have a specific procedure for directly contacting Microsoft Technical Support, be sure to review your organization's guidelines first.
  
  

To search the Microsoft Knowledge Base articles based on criteria that generated this alert, visit the Microsoft Help and Support Web site.

If you are not already doing so, consider running the Exchange tools created to help you analyze and troubleshoot your Exchange environment. These tools can help make sure that your configuration aligns with Microsoft best practices. They can also help you identify and resolve performance issues, improve mail flow, and better manage disaster recovery scenarios. To run these tools, go to the Toolbox node of the Exchange Management Console. To learn more about these tools, see Managing Tools in the Toolbox.